Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology.

doi:10.1186/s12974-026-03897-x

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Article

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology.

Journal of neuroinflammation - 9 Jun 2026

Candlish Michael, Hofmann Jan, Brösamle Desirée, Haessler Annika, DeMeglio Murphy, Skodras Angelos, Tushev Georgi, De Biasi Eloah S, Günther Stefan, Wiegandt René, Theis Heidi, De Domenico Elena, Hermann Nina Sofia, Breunig Peter, Sauerland Christina, Nilsson K Peter R, Beyer Marc D, Looso Mario, Windbergs Maike, Roeber Sigrun, Herms Jochen, Neher Jonas J, Chiocchetti Andreas G, Hefendehl Jasmin K

Abstract excerpt

Microglia are highly plastic cells that are capable of integrating subsequent insults. As the majority of Alzheimer's Disease (AD) patients also show cerebrovascular pathology, we here aimed to dissect the interactions between AD and ischemic brain injury on the microglial response to amyloid beta (Aβ) pathology. Unexpectedly, ischemic stroke in the context of cerebral β-amyloidosis drives the emergence of a...

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Identifiers

PMID: 42265753
DOI: 10.1186/s12974-026-03897-x
PMCID: PMC13292430

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