Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology

Abstract excerpt

Microglia are highly plastic cells that are capable of integrating subsequent insults. As the majority of Alzheimer’s Disease (AD) patients also show cerebrovascular pathology, we here aimed to dissect the interactions between AD and ischemic brain injury on the microglial response to amyloid beta (Aβ) pathology. Surprisingly, we find that ischemic stroke in the presence of cerebral β-amyloidosis results in the ge...

Topics

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• Alzheimer Disease
• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Apolipoproteins E
• Brain Ischemia
• Mice, Inbred C57BL
• Mice, Transgenic
• Microglia

Identifiers and source

Literature Corpus work

655de1fb-36d5-52d2-a939-1a6b458bbf57

DOI

10.64898/2025.12.09.692939