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Article

Cancer Cell Intrinsic and Immunologic Phenotypes Determine Clinical Outcomes in Basal-like Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2021

Li Christopher I, Zhang Yuping, Cieślik Marcin, Wu Yi-Mi, Xiao Lanbo, Cobain Erin, Tang Mei-Tzu C, Cao Xuhong, Porter Peggy, Guenthoer Jamie, Robinson Dan R, Chinnaiyan Arul M

Abstract excerpt

PURPOSE: Basal-like breast cancer (BLBC) is a particularly aggressive intrinsic molecular subtype of breast cancer that lacks targeted therapies. There is also no clinically useful test to risk stratify patients with BLBC. We hypothesized that a transcriptome-based phenotypic characterization of BLBC tumors and their microenvironments may overcome these challenges. EXPERIMENTAL DESIGN: We conducted a...

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PMID: 33753452
DOI: 10.1158/1078-0432.CCR-20-3890

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