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Risk prediction of Helicobacter pylori strains across Correa's cascade via intelligent analysis of genome-wide SNPs.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2026

Song Xiuling, Wang Xiangyu, Zhang Shuzhen, Li Hong, Wu Chao, Liu Huifang, Tay Chin Yen, Ma Cong, Marshall Barry J, Gu Bing, Wang Liang

Abstract excerpt

Only a minority of Helicobacter pylori (H. pylori)-infected individuals progress along Correa's cascade, and classical virulence markers do not fully explain this heterogeneity, motivating genome-wide approaches to quantify strain-level genomic risk associated with advanced lesions. We assembled 528 high-quality H. pylori whole-genome sequences spanning nonatrophic gastritis (NAG), atrophic gastritis (AG),...

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PMID: 42263134
DOI: 10.1073/pnas.2603926123
PMCID: PMC13273288

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