Article
Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments.
Gut - 1 Oct 2018
Noto Jennifer M, Chopra Abha, Loh John T, Romero-Gallo Judith, Piazuelo M Blanca, Watson Mark, Leary Shay, Beckett Amber C, Wilson Keith T, Cover Timothy L, Mallal Simon, Israel Dawn A, Peek Richard M
Abstract excerpt
OBJECTIVE: Helicobacter pylori is the strongest risk factor for gastric cancer; however, the majority of infected individuals do not develop disease. Pathological outcomes are mediated by complex interactions among bacterial, host and environmental constituents, and two dietary factors linked with gastric cancer risk are iron deficiency and high salt. We hypothesised that prolonged adaptation of H. pylori to in...
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