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Article

Polygenic Risk Scores for Myopia: A Systematic Review of Predictive Performance and Clinical Potential.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) - 1 Jul 2026

Mao Bin, Dong Xing-Xuan, Li Dan-Lin, Fan Qiao, Pan Chen-Wei

Abstract excerpt

PURPOSE: Given the genetic predisposition to myopia, polygenic risk scores (PRS) have been proposed as a tool for early risk identification. This study assessed the discriminatory ability of PRS in myopia prediction systematically and compared the performance of different PRS models. METHODS: This systematic review followed PRISMA guidelines and was preregistered in PROSPERO (CRD420251180577). Five databases...

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PMID: 41894138
DOI: 10.1007/s44402-026-00062-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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