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Article

Within-host SARS-CoV-2 diversity in immunocompromised patients during acute infection.

Journal of virology - 21 Jul 2026

Vargas Deninson Alejandro, Albornoz Ludwig L, Peña-Morales Mateo, Ortiz Rojas Helen Johana, Breban Mallery I, Grubaugh Nathan D, Hahn Anne M

Abstract excerpt

Within-host SARS-CoV-2 diversity during acute infection is largely characterized by low-frequency intra-host single-nucleotide variants (iSNVs), but whether early iSNV patterns differ by immune status remains unclear. We analyzed biobanked diagnostic specimens from adults with RT-qPCR-confirmed SARS-CoV-2 infection collected in Cali, Colombia, between 2020 and 2022. Immunocompromised cases sampled during the...

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Identifiers

PMID: 42262131
DOI: 10.1128/jvi.02224-25
PMCID: PMC13386825

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