Causal relationship between birth weight, uric acid levels, and risk of gout: New insights from a bidirectional two-sample Mendelian randomization study.

Abstract excerpt

Bidirectional two-sample Mendelian randomization (MR) was used to evaluate the potential causal effects of birth weight and uric acid levels (the exposures) and the development of gout (the outcome). Genetic instruments derived from aggregated genome-wide association study data of European ancestry were used to investigate the associations between birth weight (261,932 samples, 9,851,867 single-nucleotide...

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