Article
Relationship between birth weight and chronic kidney disease: evidence from systematics review and two-sample Mendelian randomization analysis.
Human molecular genetics - 3 Aug 2020
Yu Xinghao, Yuan Zhongshang, Lu Haojie, Gao Yixin, Chen Haimiao, Shao Zhonghe, Yang Jiaji, Guan Fengjun, Huang Shuiping, Zeng Ping
Abstract excerpt
Observational studies showed an inverse association between birth weight and chronic kidney disease (CKD) in adulthood existed. However, whether such an association is causal remains fully elusive. Moreover, none of prior studies distinguished the direct fetal effect from the indirect maternal effect. Herein, we aimed to investigate the causal relationship between birth weight and CKD and to understand the...
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