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Article

Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2021

Yu Xing-Hao, Wei Yong-Yue, Zeng Ping, Lei Shu-Feng

Abstract excerpt

The relationship between birth weight and osteoporosis was inconsistent in previous observational studies. Therefore, we performed a systematic evaluation to determine the inconsistent relationship and further make causal inference based on the UK Biobank datasets (~500,000 individuals) and individual/summary-level genetic datasets. Observational analyses found consistent negative associations either between...

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Identifiers

PMID: 34105796
DOI: 10.1002/jbmr.4316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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