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Article

Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study.

International journal of epidemiology - 8 Feb 2023

Decina Caitlin S, Hopkins Rhian, Bowden Jack, Shields Beverly M, Lawlor Deborah A, Warrington Nicole M, Evans David M, Freathy Rachel M, Beaumont Robin N

Abstract excerpt

BACKGROUND: Higher urate levels are associated with higher systolic blood pressure (SBP) in adults, and in pregnancy with lower offspring birthweight. Mendelian randomization (MR) analyses suggest a causal effect of higher urate on higher SBP and of higher maternal SBP on lower offspring birthweight. If urate causally reduces birthweight, it might confound the effect of SBP on birthweight. We therefore tested for...

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Identifiers

PMID: 36191079
DOI: 10.1093/ije/dyac186
PMCID: PMC9908052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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