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Article

Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells.

Open biology - 1 Jun 2024

McAlary Luke, Nan Jeremy R, Shyu Clay, Sher Mine, Plotkin Steven S, Cashman Neil R

Abstract excerpt

Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Currently, over 220 (mostly missense) ALS-causing mutations in the SOD1 protein have been identified, indicating that common structural features are responsible for aggregation and toxicity. Using in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38835240
DOI: 10.1098/rsob.230418
PMCID: PMC11285818

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells.PMID 38835240Read ↗

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