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Article

Destabilized Soluble SOD1 Species as Potential Determinants of Disease Severity in Familial Amyotrophic Lateral Sclerosis.

ACS chemical neuroscience - 15 Apr 2026

Hirata Yoko, Kobatake Yui, Koyama Hiroko, Furuta Kyoji, Takemori Hiroshi, Kamatari Yuji O

Abstract excerpt

Mutations in the Cu/Zn superoxide dismutase (SOD1) gene are linked to familial amyotrophic lateral sclerosis (ALS), yet the identity of the toxic molecular species remains unclear. We investigated the relationship between protein misfolding and pathogenicity by expressing GFP-tagged wild-type and mutant SOD1 (A4V, H46R, G93A) in mouse hippocampal HT22 cells. Western blotting under nonreducing conditions suggested...

Topics

Animals
Amyotrophic Lateral Sclerosis
Superoxide Dismutase-1
Mice
Humans
Superoxide Dismutase
Protein Folding
Mutation
Cell Line
Hippocampus
Severity of Illness Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41894255
DOI: 10.1021/acschemneuro.5c00668

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Destabilized Soluble SOD1 Species as Potential Determinants of Disease Severity in Familial Amyotrophic Lateral Sclerosis.PMID 41894255Read ↗

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