Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fighting against amyotrophic lateral sclerosis (ALS) with flavonoids: a computational approach to inhibit superoxide dismutase (SOD1) mutant aggregation.

Journal of biomolecular structure & dynamics - 1 Jan 2025

Noorbakhsh Varnosfaderani Seyed Mostafa, Sadat Haeri Melika, Arian Ali Sam, Yousefi Rad Ali, Yazdanpour Mohammad, Mojahedian Fatemeh, Yaghoubzad-Maleki Mohammad, Zalpoor Hamidreza, Baziyar Payam, Nabi-Afjadi Mohsen

Abstract excerpt

Protein aggregation is a biological process that occurs when proteins misfold. Misfolding and aggregation of human superoxide dismutase (hSOD1) cause a neurodegenerative disease called amyotrophic lateral sclerosis (ALS). Among the mutations occurring, targeting the E21K mutation could be a good choice to understand the pathological mechanism of SOD1 in ALS, whereof it significantly reduces life hopefulness in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Flavonoids
Share to Hydrogen Bonding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Protein Aggregates

Share to Protein Aggregation, Pathological

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 37975411
DOI: 10.1080/07391102.2023.2281641

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fighting against amyotrophic lateral sclerosis (ALS) with flavonoids: a computational approach to inhibit superoxide dismutase (SOD1) mutant aggregation.PMID 37975411Read ↗

Probing the polyphenolic flavonoid, morin as a highly efficacious inhibitor against amyloid(A4V) mutant SOD1 in fatal amyotrophic lateral sclerosis.Semantic proximity Read ↗

Polyphenolic flavonoid compounds act as the inhibitory potential of aggregation process: Implications for the prevention and therapeutics against FALS-associated D101G SOD1 mutant.Semantic proximity Read ↗

A computational strategy for therapeutic development against superoxide dismutase (SOD1) amyloid formation: effect of polyphenols on the various events in the aggregation pathway.Semantic proximity Read ↗

Myricetin: A Potent Anti-Amyloidogenic Polyphenol against Superoxide Dismutase 1 Aggregation.Semantic proximity Read ↗

Investigating the impact of SOD1 mutations on amyotrophic lateral sclerosis progression and potential drug repurposing through in silico analysis.Semantic proximity Read ↗

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.Semantic proximity Read ↗

Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosisSemantic proximity Read ↗

Unveiling promising inhibitors of superoxide dismutase 1 (SOD1) for therapeutic interventions.Semantic proximity Read ↗

Bisdemethoxycurcumin, a novel potent polyphenolic compound, effectively inhibits the formation of amyloid aggregates in ALS-associated hSOD1 mutant (L38R).Semantic proximity Read ↗

Quercetin and Baicalein Act as Potent Antiamyloidogenic and Fibril Destabilizing Agents for SOD1 Fibrils.Semantic proximity Read ↗

Inhibitory effect of silymarin on amyloid formation in ALS-associated hSOD1 P66R mutant.Semantic proximity Read ↗

In silico analysis of SOD1 aggregation inhibition modes of tertiary amine pyrazolone and pyrano coumarin ferulate as ALS drug candidates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.