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Article

Intravenous diazepam application in a departmental convulsive status epilepticus protocol with CYP2C19 polymorphisms: a pediatric prospective cohort study.

BMC pharmacology & toxicology - 5 Jun 2026

Seker Gezici Muazzez, Turan Caner, Ayyildiz Emecen Durdugul, Kanmaz Seda, Isik Esra, Yurtseven Ali, Atik Tahir, Yilmaz Sanem Keskin, Tekgul Hasan, Saz Eylem Ulas

Abstract excerpt

BACKGROUND: Individual variability of therapeutic response and adverse effects of diazepam is frequently observed in pediatric cohorts. It might be related to the genetic polymorphisms in cytochrome P450 2C19 (CYP2C19), a principal enzyme mediating diazepam metabolism. OBJECTIVES: To investigate the association between CYP2C19*2 (c.681G > A), CYP2C19*3 (c.636G > A), and CYP2C19*17 (-806 C > T) polymorphisms and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42249455
DOI: 10.1186/s40360-026-01159-3
PMCID: PMC13471298

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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