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Therapeutic drug monitoring and CYP2C19 genotyping guide the application of voriconazole in children

1 Aug 2022

Abstract excerpt

Background: This study used therapeutic drug monitoring (TDM) and CYP2C19 gene polymorphism analysis to explore the efficacy and safety of different doses of voriconazole (VCZ) for the clinical treatment of pediatric patients, with the aim of providing guidelines for individualized antifungal therapy in children. Methods: Our study enrolled 94 children with 253 VCZ concentrations. The genotyping of CYP2C19 was...

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PMID: 36072540
DOI: 10.21037/tp-22-156

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