Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia.

Clinical pharmacology and therapeutics - 1 Dec 2005

Inomata Shinichi, Nagashima Atsushi, Itagaki Fumio, Homma Masato, Nishimura Masuhiro, Osaka Yoshiko, Okuyama Kazuhiko, Tanaka Einosuke, Nakamura Takako, Kohda Yukinao, Naito Shinsaku, Miyabe Masayuki, Toyooka Hidenori

Abstract excerpt

OBJECTIVES: Diazepam is widely used to relieve preoperative anxiety in patients. The objective of this study was to investigate the effects of polymorphism in CYP2C19 and the effects of CYP3A4 messenger ribonucleic acid (mRNA) content in blood on recovery from general anesthesia and on diazepam p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia, General
Share to Area Under Curve

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryl Hydrocarbon Hydroxylases

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP3A

Share to Diazepam

Share to Hypnotics and Sedatives

Share to Mixed Function Oxygenases

Source

Identifiers

PMID: 16338280
DOI: 10.1016/j.clpt.2005.08.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16338280-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia.PMID 16338280Read ↗

Effect on emergence from anesthesia following induction with diazepam and its association with CYP2C9, CYP2C19 and CYP3A4 gene polymorphismsSemantic proximity Read ↗

Association between CYP2C19 and CYP2B6 phenotypes and the pharmacokinetics and safety of diazepam.Semantic proximity Read ↗

Intravenous diazepam application in a departmental convulsive status epilepticus protocol with CYP2C19 polymorphisms: a pediatric prospective cohort study.Semantic proximity Read ↗

Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment.Semantic proximity Read ↗

Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status.Semantic proximity Read ↗

Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepinesSemantic proximity Read ↗

How do CYP2C19*2 and CYP2C19*17 genetic polymorphisms affect the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome?Semantic proximity Read ↗

The pharmacogenetics of medications used in general anesthesia.Semantic proximity Read ↗

Impact of CYP2C9 polymorphism found in the Chinese population on the metabolism of propofol in vitro.Semantic proximity Read ↗

Population Estimation of the Effects of Cytochrome P450 2C9 and 2C19 Polymorphisms on Phenobarbital Clearance in JapaneseSemantic proximity Read ↗

Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and PharmacodynamicsSemantic proximity Read ↗

CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.