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How do CYP2C192 and CYP2C1917 genetic polymorphisms affect the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome?

Drug metabolism and personalized therapy - 5 Mar 2020

Skryabin Valentin Yu, Zastrozhin Mikhail S, Torrado Marco V, Grishina Elena A, Ryzhikova Kristina A, Shipitsyn Valery V, Galaktionova Tatiana E, Sorokin Alexander S, Bryun Evgeny A, Sychev Dmitry A

Abstract excerpt

Background Diazepam is one of the most commonly prescribed tranquilizers for therapy of alcohol withdrawal syndrome (AWS). Despite its popularity, there is currently no precise information on the effect of genetic polymorphisms on its efficacy and safety. The objective of our study was to investigate the effect of CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the efficacy and safety of diazepam in patients...

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Share to Cytochrome P-450 CYP2C19
Share to Diazepam

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Genotype

Share to Polymorphism, Genetic

Share to Substance Withdrawal Syndrome

Source

Identifiers

PMID: 32134726
DOI: 10.1515/dmpt-2019-0026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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