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Article

Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures.

Archives of disease in childhood - 1 Jun 2012

Lee Soon Min, Chung Jae Yong, Lee Young Mock, Park Min Soo, Namgung Ran, Park Kook In, Lee Chul

Abstract excerpt

BACKGROUND: Phenobarbital (PB), commonly used as the preferred treatment for neonatal seizure, is a drug that requires careful dose adjustments based on therapeutic drug monitoring. It has been reported that PB metabolism was affected by cytochrome P450 (CYP)2C19 polymorphisms in adults requiring dose adjustment. AIM: This study aimed to evaluate the effects of CYP2C19 genetic polymorphisms on PB pharmacokinetics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22331680
DOI: 10.1136/archdischild-2011-300538

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