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Article

The association between CYP2C9/2C19 polymorphisms and phenytoin maintenance doses in Asian epileptic patients: A systematic review and meta-analysis .

International journal of clinical pharmacology and therapeutics - 1 Jul 2018

Liao Kai, Liu Yong, Ai Chun-Zhi, Yu Xi, Li Wei

Abstract excerpt

OBJECTIVE: Therapeutic response to phenytoin (PHT), a first-line antiepileptic drug (AED), is highly variable, in part likely due to genetic factors. Genetic polymorphisms in cytochrome P450 (CYP) 2C9 and CYP2C19 are expected to affect the metabolism of PHT and consequently affect its maintenance doses. We aimed to clarify the effects of genetic polymorphisms in both enzymes on daily PHT maintenance dosage in...

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Identifiers

PMID: 29628024
DOI: 10.5414/CP203083

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