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Article

Association between CYP2C19 and CYP2B6 phenotypes and the pharmacokinetics and safety of diazepam.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2022

Zubiaur Pablo, Figueiredo-Tor Laura, Villapalos-García Gonzalo, Soria-Chacartegui Paula, Navares-Gómez Marcos, Novalbos Jesús, Matas Miriam, Calleja Sofía, Mejía-Abril Gina, Román Manuel, Ochoa Dolores, Abad-Santos Francisco

Abstract excerpt

Diazepam is a benzodiazepine (BZD) used worldwide for a variety of conditions. Long-term use of diazepam increases the risk for developing tolerance and dependence and for the occurrence of adverse drug reactions (ADRs). CYP3A4 and CYP2C19 mainly metabolize diazepam and are therefore the primary pharmacogenetic candidate biomarkers. In this work, we aimed to explore the impact of CYP3A4 and CYP2C19 phenotypes and...

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PMID: 36162369
DOI: 10.1016/j.biopha.2022.113747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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