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Article

The associations of human genetic variations with airway microbiome, environmental exposures, and respiratory health.

mSystems - 18 Aug 2026

Xu Shifen, Yang Lei, Gao Jingyuan, Shi Yunfeng, Tang Xin, Cai Hanqin, Yang Liling, Han Yuanyuan, Lin Lifeng, Meng Ruilin, Sun Jiufeng, Guan Wei-Jie, Tang Tao, Shu Wensheng, Cao Chao, Zheng Xue-Yan, Wang Zhang, Yi Xinzhu

Abstract excerpt

The intricate interactions between environmental exposures, the respiratory microbiome, and host genetic variations remain inadequately understood in the context of respiratory health. This study utilized sputum metagenomic data from 1,651 individuals in our previous cohort to elucidate these associations. Mendelian randomization indicated that air pollutants (e.g., SO2, CO, and PM2.5) were associated with lung...

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Share to Air Pollutants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Microbiota

Share to Polymorphism, Single Nucleotide

Share to Pulmonary Disease, Chronic Obstructive

Share to Respiratory System

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Source

Open in PubMed Open full text

Identifiers

PMID: 42523106
DOI: 10.1128/msystems.00442-26
PMCID: PMC13483325

Genes

CCDC57
DNAJC18
FAM110D
MEOX1
USP36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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