Article
Challenge of Diagnostic Criteria for Diffuse Hemispheric Glioma (DHG), H3 G34-Mutant: A Case of DHG Without H3.3 Gene Alteration.
Neuropathology and applied neurobiology - 1 Apr 2026
Hu Tianran, Liu Xiaojia, Lan Yang, Ge Jia, Wang Lihong, Wang Jiao, Wei Sen, Chen Hong, Luo Tao
Abstract excerpt
We present a case of diffuse hemispheric glioma (DHG), H3 G34-mutant, NEC. Postoperative histological examination and DNA sequencing detected some features consistent with DHG, H3 G34-mutant; however, no canonical H3 alterations or ATRX variants were detected. The diagnosis could only be established based on the DNA methylation profiling result. In light of these distinctive molecular findings, we propose some...
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