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Article

Sex differences and alcohol modulation in the heritability of MASLD: a twin study of the 2023 definition.

Human genetics - 5 Jun 2026

Li Jingxian, Zhong Jiping, Luo Jia, Wang Tong, Xu Chunsheng, Wang Weijing, Tian Xiaocao, Zhang Dongfeng

Abstract excerpt

The baseline heritability of the newly defined metabolic dysfunction-associated steatotic liver disease (MASLD) is unknown. Given that sex and alcohol consumption are well-recognized determinants of fatty liver disease, it is important to understand whether they are also associated with variation in its underlying genetic susceptibility. We aimed to quantify the baseline heritability and investigate these...

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PMID: 42247012
DOI: 10.1007/s00439-026-02837-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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