Pathogenesis of diffuse large B cell lymphoma proteogenotypes.

doi:10.1016/j.ccell.2026.05.008

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Article

Pathogenesis of diffuse large B cell lymphoma proteogenotypes.

Cancer cell - 13 Jul 2026

Enssle Julius C, Häupl Björn, Qoku Arber, Wang Boya, Wright George W, Barrans Sharon, Zhou Yulai, Care Matthew A, Burton Cathy, Gribbin Caitlin, Ziello Jennifer, Weirather Jason, Dai Yibo, Kizhakeyil Atish, Li Xubin, Phelan James D, Kanangat Smriti, Eckert Stephan, Scheich Sebastian, Wolf Sebastian, Huang Da Wei, Jakob Josefine, Perner Sebastian P, Di Fonzo Andrea, Pape Martine, Bodach Marion, Jahn Dominique, Plessmann Uwe, Staiger Annette M, Ott German, Berning Philipp, Lenz Georg, Hodson Daniel J, Kuster Bernhard, Schmitz Roland, Urlaub Henning, Green Michael R, Melnick Ari M, Tooze Reuben, Mlynarczyk Coraline, Inghirami Giorgio, Buettner Florian, Staudt Louis M, Oellerich Thomas

Abstract excerpt

The clinical and molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) is incompletely understood. By integrating proteomic, transcriptomic, and genomic data from 478 DLBCL tumors, we identify seven DLBCL proteogenotypes (PGs) reflecting specific pathophysiological features that span known molecular subtypes. PG4 is associated with poor outcome independent of established risk factors such as...

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PMID: 42242231
DOI: 10.1016/j.ccell.2026.05.008

Genes

MYC
BTG1
TCF3

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