Article
Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.
The New England journal of medicine - 12 Apr 2018
Schmitz Roland, Wright George W, Huang Da Wei, Johnson Calvin A, Phelan James D, Wang James Q, Roulland Sandrine, Kasbekar Monica, Young Ryan M, Shaffer Arthur L, Hodson Daniel J, Xiao Wenming, Yu Xin, Yang Yandan, Zhao Hong, Xu Weihong, Liu Xuelu, Zhou Bin, Du Wei, Chan Wing C, Jaffe Elaine S, Gascoyne Randy D, Connors Joseph M, Campo Elias, Lopez-Guillermo Armando, Rosenwald Andreas, Ott German, Delabie Jan, Rimsza Lisa M, Tay Kuang Wei Kevin, Zelenetz Andrew D, Leonard John P, Bartlett Nancy L, Tran Bao, Shetty Jyoti, Zhao Yongmei, Soppet Dan R, Pittaluga Stefania, Wilson Wyndham H, Staudt Louis M
Abstract excerpt
BACKGROUND: Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B-cell-like [ABC], germinal-center B-cell-like [GCB], and unclassified) according to cell of origin that are associated with a differential response to chemotherapy and targeted agents. We sought to extend these findings by identifying genetic...
Topics
- Antineoplastic Combined Chemotherapy Protocols
- Biopsy
- Epigenesis, Genetic
- Exome
- Gene Expression Profiling
- Genetic Heterogeneity