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Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma

9 Apr 2023

Abstract excerpt

Abstract Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, and fluorescence in situ hybridization in 337 newly diagnosed DLBCL patients, we established a simplified 38-gene algorithm (termed ‘LymphPlex’) based on the information on mutations of 35 genes and rearrangements of...

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PMID: 37032379
DOI: 10.1038/s41392-023-01358-y

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