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Biological heterogeneity in diffuse large B-cell lymphoma

1 Nov 2023

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is heterogeneous both in clinical outcomes and the underlying disease biology. Over the last 2 decades, several different approaches for dissecting biological heterogeneity have emerged. Gene expression profiling (GEP) stratifies DLBCL into 3 broad groups (ABC, GCB, and DZsig/MHG), each with parallels to different normal mature B cell developmental states and prognostic...

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PMID: 38151380
DOI: 10.1053/j.seminhematol.2023.11.006

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