Article
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2013
Zhang Jenny, Grubor Vladimir, Love Cassandra L, Banerjee Anjishnu, Richards Kristy L, Mieczkowski Piotr A, Dunphy Cherie, Choi William, Au Wing Yan, Srivastava Gopesh, Lugar Patricia L, Rizzieri David A, Lagoo Anand S, Bernal-Mizrachi Leon, Mann Karen P, Flowers Christopher, Naresh Kikkeri, Evens Andrew, Gordon Leo I, Czader Magdalena, Gill Javed I, Hsi Eric D, Liu Qingquan, Fan Alice, Walsh Katherine, Jima Dereje, Smith Lisa L, Johnson Amy J, Byrd John C, Luftig Micah A, Ni Ting, Zhu Jun, Chadburn Amy, Levy Shawn, Dunson David, Dave Sandeep S
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome and exome sequencing, we characterized the genetic diversity of DLBCL. In all, we sequenced 73 DLBCL primary tumors (34 with matched normal DNA). Separately, we...
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