Decoding the Heterogeneity of Diffuse Large B-Cell Lymphomas: A Comprehensive Genetic, Transcriptomic, and Phenotypic Profiling of B-Cell Lymphoma Cell Lines.

doi:10.1002/hon.70228

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Decoding the Heterogeneity of Diffuse Large B-Cell Lymphomas: A Comprehensive Genetic, Transcriptomic, and Phenotypic Profiling of B-Cell Lymphoma Cell Lines.

Hematological oncology - 1 Sept 2026

Pérez-Aguilera Marina, Pedrosa Lucía, Gómez Sagrario, Salazar-Ortego Sara, Fernández-Miranda Ismael, Muñoz-Viana Rafael, Martín-Acosta Paloma, Martín-Lunas Beatriz L, Jimeno Rebeca, Yanguas-Casás Natalia, Horcajo Beatriz, Roncador Giovana, Martínez-Climent José A, Ortega-Molina Ana, Sánchez-Beato Margarita

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is the most prevalent form of non-Hodgkin lymphoma, exhibiting significant molecular and clinical heterogeneity. Advances in classification integrating phenotypic, genetic, and transcriptomic features have improved diagnosis and prognosis. However, a comprehensive and integrated molecular characterization of DLBCL cell lines is still lacking, which limits their optimal use as...

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PMID: 42555529
DOI: 10.1002/hon.70228
PMCID: PMC13440701

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