Article
HPV16 genetic variation provides evidence of positive natural selection driven by HLA class I.
Nature communications - 2 Jun 2026
Nelson Chase W, Mishra Sambit K, Dean Michael, Ohuigin Colm, Burk Robert D, Zhu Bin, Wang Difei, Burdett Laurie, Viard Mathias, Lee Hyo Jung, Koestler Aimee J, Narechania Apurva, Chen Zigui, Wentzensen Nicolas, Schiffman Mark, Clifford Gary M, Suh-Burgmann Elizabeth, Lorey Thomas, Carrington Mary, Yeager Meredith, Mirabello Lisa
Abstract excerpt
Human papillomavirus type 16 (HPV16) causes more cancer than any other virus. However, most HPV16 infections are controlled by the host's immune system and it remains unclear how viral and host genetic variation contribute to infection outcomes. Here, we analyze 4704 HPV16 whole genomes to identify 56 viral codons putatively under positive natural selection to change their amino acids, with evidence including...
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