Article
Genome-Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical Cancer.
Journal of medical virology - 1 Feb 2025
Beckhaus Theresa, Kachuri Linda, Nakase Taishi, Schürmann Peter, Eisenblätter Rieke, Geerts Maya, Böhmer Gerd, Strauß Hans-Georg, Hirchenhain Christine, Schmidmayr Monika, Müller Florian, Fasching Peter A, Häfner Norman, Luyten Alexander, Jentschke Matthias, Hillemanns Peter, O'Mara Tracy A, Francis Stephen S, Witte John S, Dörk Thilo, Ramachandran Dhanya
Abstract excerpt
Infection by high-risk human papillomavirus is known to exacerbate cervical cancer development. The host immune response is crucial in disease regression. Large-scale genetic association studies for cervical cancer have identified few susceptibility variants, mainly at the human leukocyte antigen locus on chromosome 6. We hypothesized that the host immune response modifies cervical cancer risk and performed three...
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