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Article

Deep Sequencing of HPV16 E6 Region Reveals Unique Mutation Pattern of HPV16 and Predicts Cervical Cancer.

Microbiology spectrum - 31 Aug 2022

Ai Wenchao, Wu Chuanyong, Jia Liqing, Xiao Xiao, Xu Xuewen, Ren Min, Xue Tian, Zhou Xiaoyan, Wang Ying, Gao Chunfang

Abstract excerpt

The genetic diversity of human papillomavirus (HPV) 16 within cervical cells and tissue is usually associated with persistent virus infection and precancerous lesions. To explore the HPV16 mutation patterns contributing to the cervical cancer (CC) progression, a total of 199 DNA samples from HPV16-positive cervical specimens were collected and divided into high-grade squamous intraepithelial lesion (HSIL) and the...

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Identifiers

PMID: 35735983
DOI: 10.1128/spectrum.01401-22
PMCID: PMC9430801

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