Article

Divergence of HPV16 variants reflects loci undergoing inter-host positive selection, potentially immunologic selection

2017-07-03

Abstract excerpt

Human papillomavirus type 16 (HPV16) is the most carcinogenic HPV, causing >50% of cervical cancers. Its unique oncogenicity is unsolved, e.g., the second most carcinogenic type (HPV18, causing ~16% of cancers) is relatively distantly related to HPV16. Mirabello et al. recently reported on viral genome data from 3,215 HPV positive specimens from women undergoing cervical cancer screening at Kaiser Permanente Nort...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9e33e1c-0ae1-5ee1-af8a-700b4868a7f7
DOI: 10.7287/peerj.preprints.3070v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Divergence of HPV16 variants reflects loci undergoing inter-host positive selection, potentially immunologic selectionDOI 10.7287/peerj.preprints.3070v1Read

HPV16 genetic variation provides evidence of positive natural selection driven by HLA class I.Semantic proximity Read

Changes in intra-host genetic diversity according to lesion severity in longitudinal HPV16 samples.Semantic proximity Read

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.Semantic proximity Read

Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses.Semantic proximity Read

Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology.Semantic proximity Read

Changes in intrahost genetic diversity according to lesion severity in longitudinal HPV16 samples.Semantic proximity Read

Whole-Genome Sequencing and Variant Analysis of Human Papillomavirus 16 Infections.Semantic proximity Read

Evolution and taxonomic classification of human papillomavirus 16 (HPV16)-related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67.Semantic proximity Read

Human papillomavirus type 16 genetic variants: phylogeny and classification based on E6 and LCR.Semantic proximity Read

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosisSemantic proximity Read

Viral whole genome sequencing reveals high variations in APOBEC3 editing between HPV risk categories.Semantic proximity Read

HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus.Semantic proximity Read