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Article

The causal role of plasma metabolites in breast cancer susceptibility mediated by immune cells: A two-sample Mendelian randomization analysis.

Medicine - 29 May 2026

Sun Zhe, Ge Fei, Duan Wenjing, Qian Jinxian, Chen Liang

Abstract excerpt

Breast carcinoma (BC) is a significant oncological issue, categorized based on estrogen receptor (ER) status into ER-positive and ER-negative types. The ER-positive variant relies on hormonal signaling, whereas the ER-negative form is characterized by increased aggressiveness. There exists a potential interplay between plasma metabolites and immune effectors that may influence BC susceptibility, although the...

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Breast Neoplasms
CD14 gene
CD4 gene
Genetic Predisposition to Disease
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Estrogen

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Identifiers

PMID: 42216331
DOI: 10.1097/MD.0000000000049014
PMCID: PMC13225498

Genes

CD14
CD28
CD38
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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