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Causal pathways in Lymphoma: The role of serum metabolites and immune cells determined by Mendelian randomization.

International immunopharmacology - 10 Jan 2025

Zhuang Xin, Zhang Xia, Yin Qingning, Yang Rong, Man Xiaoying, Wang Ruochen, Shi Yifen, Wang Hailin, Jiang Songfu

Abstract excerpt

BACKGROUND: Prior research has demonstrated significant roles of metabolites and immune cells in the progression of lymphoma. Mendelian randomization studies have been conducted to assess the causal relationships among serum metabolites, immune cells, and lymphoma, further exploring the mediating role of serum metabolites. METHODS: Using summary-level data from genome-wide association studies (GWAS), we applied...

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PMID: 39591822
DOI: 10.1016/j.intimp.2024.113593

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