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Article

Causal effects and metabolites mediators between immune cell and risk of colorectal cancer: a Mendelian randomization study.

Frontiers in immunology - 1 Jan 2024

Yang Qian, Duan Bixia, Yue Jian, Zhang Donglin, Chen Xueping, Shi Mengjia, Kan Jie, Li Ruochan, Li Hongda, Gan Lin

Abstract excerpt

Objective: The involvement of immune cells in colorectal cancer (CRC) and their interplay with metabolic disorders are yet to be fully elucidated. This study examines how peripheral immune cells, inferred genetically, affect CRC and investigates the intermediary roles of metabolites. Methods: We employed a two-sample bidirectional Mendelian randomization (MR) approach to assess the causal influence of immune...

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Colorectal Neoplasms
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39346920
DOI: 10.3389/fimmu.2024.1444222
PMCID: PMC11428109

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