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Article

Region-based morphometry in Parkinson's disease patients with GBA mutation and its predictive role for cognition after STN-DBS.

Parkinsonism & related disorders - 1 Jul 2026

Reimer J, Schumann F, Gruber D, Schneider G H, Krause T, Kühn A A, Krause P

Abstract excerpt

BACKGROUND: Patients with Parkinson's disease (PD) who carry Glucocerebrosidase 1 (GBA) mutations (GBA + PD) demonstrate a more aggressive motor and non-motor disease course. While subthalamic nucleus deep brain stimulation (STN-DBS) is effective for advanced PD, its cognitive impact in GBA + PD patients remains controversial, and individual predictors of DBS outcome are lacking. METHODS: We applied region-based...

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Identifiers

PMID: 42214115
DOI: 10.1016/j.parkreldis.2026.108355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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