Article
Independent susceptibility markers for atrial fibrillation on chromosome 4q25.
Circulation - 7 Sept 2010
Lubitz Steven A, Sinner Moritz F, Lunetta Kathryn L, Makino Seiko, Pfeufer Arne, Rahman Rosanna, Veltman Caroline E, Barnard John, Bis Joshua C, Danik Stephan P, Sonni Akshata, Shea Marisa A, Del Monte Federica, Perz Siegfried, Müller Martina, Peters Annette, Greenberg Steven M, Furie Karen L, van Noord Charlotte, Boerwinkle Eric, Stricker Bruno H C, Witteman Jacqueline, Smith Jonathan D, Chung Mina K, Heckbert Susan R, Benjamin Emelia J, Rosand Jonathan, Arking Dan E, Alonso Alvaro, Kääb Stefan, Ellinor Patrick T
Abstract excerpt
BACKGROUND: Genetic variants on chromosome 4q25 are associated with atrial fibrillation (AF). We sought to determine whether there is more than 1 susceptibility signal at this locus. METHODS AND RESULTS: Thirty-four haplotype-tagging single-nucleotide polymorphisms (SNPs) at the 4q25 locus were genotyped in 790 case and 1177 control subjects from Massachusetts General Hospital and tested for association with AF....
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