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Article

Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.

Journal of the American College of Cardiology - 25 Sept 2012

Ritchie Marylyn D, Rowan Shane, Kucera Gayle, Stubblefield Tanya, Blair Marcia, Carter Shannon, Roden Dan M, Darbar Dawood

Abstract excerpt

OBJECTIVES: The aim of this study was to test the hypothesis that 2 common polymorphisms in the chromosome 4q25 region that have been associated with atrial fibrillation (AF) contribute to the variable penetrance of familial AF. BACKGROUND: Although mutations in ion channels, gap junction proteins, and signaling molecules have been described for Mendelian forms of AF, penetrance is highly variable. Recent studies...

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Share to Atrial Fibrillation
Share to Atrial Natriuretic Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

Share to Homeobox Protein Nkx-2.5

Share to Ion Channels

Share to KCNQ1 Potassium Channel

Share to NAV1.5 Voltage-Gated Sodium Channel

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Source

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Identifiers

PMID: 22818067
DOI: 10.1016/j.jacc.2012.04.030
PMCID: PMC3448817

Genes

KCNA5
KCNQ1
NPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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