Article
Variants conferring risk of atrial fibrillation on chromosome 4q25.
Nature - 19 Jul 2007
Gudbjartsson Daniel F, Arnar David O, Helgadottir Anna, Gretarsdottir Solveig, Holm Hilma, Sigurdsson Asgeir, Jonasdottir Adalbjorg, Baker Adam, Thorleifsson Gudmar, Kristjansson Kristleifur, Palsson Arnar, Blondal Thorarinn, Sulem Patrick, Backman Valgerdur M, Hardarson Gudmundur A, Palsdottir Ebba, Helgason Agnar, Sigurjonsdottir Runa, Sverrisson Jon T, Kostulas Konstantinos, Ng Maggie C Y, Baum Larry, So Wing Yee, Wong Ka Sing, Chan Juliana C N, Furie Karen L, Greenberg Steven M, Sale Michelle, Kelly Peter, MacRae Calum A, Smith Eric E, Rosand Jonathan, Hillert Jan, Ma Ronald C W, Ellinor Patrick T, Thorgeirsson Gudmundur, Gulcher Jeffrey R, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. Recent studies have provided evidence of a genetic contribution to AF. Mutations in potassium-channel genes have been associated...
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