Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.

doi:10.1093/eurheartj/ehn578

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Article

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.

European heart journal - 1 Apr 2009

Kääb Stefan, Darbar Dawood, van Noord Charlotte, Dupuis Josée, Pfeufer Arne, Newton-Cheh Christopher, Schnabel Renate, Makino Seiko, Sinner Moritz F, Kannankeril Prince J, Beckmann Britt M, Choudry Subbarao, Donahue Brian S, Heeringa Jan, Perz Siegfried, Lunetta Kathryn L, Larson Martin G, Levy Daniel, MacRae Calum A, Ruskin Jeremy N, Wacker Annette, Schömig Albert, Wichmann H-Erich, Steinbeck Gerhard, Meitinger Thomas, Uitterlinden André G, Witteman Jacqueline C M, Roden Dan M, Benjamin Emelia J, Ellinor Patrick T

Abstract excerpt

AIMS: A recent genome-wide association study identified a haplotype block on chromosome 4q25 associated with atrial fibrillation (AF). We sought to replicate this association in four independent cohorts. METHODS AND RESULTS: The Framingham Heart Study and Rotterdam Study are community-based longitudinal studies. The Vanderbilt AF Registry and German AF Network (AFNet) are case-control studies. Participants with...

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PMID: 19141561
DOI: 10.1093/eurheartj/ehn578
PMCID: PMC2663727

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