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Article

PhoPR variants from several phylogenetic lineages of tuberculosis bacilli respond differently to extracellular signals.

mBio - 8 Jul 2026

Meunier Eva, de Matos E Silva Carlos Adriano, Malaga Wladimir, Rengel David, Mourey Lionel, Astarie-Dequeker Catherine, Guilhot Christophe

Abstract excerpt

The global spread of Mycobacterium tuberculosis (MTB) is facilitated by airborne transmission, a low infectious dose, and the pathogen's ability to persist in a latent state. Despite sharing over 99% genomic identity, MTB strains and lineages show significant variability in transmissibility. We hypothesized that natural polymorphisms in the two-component regulatory system (TCS) PhoP-PhoR (PhoPR), a major...

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Share to Bacterial Proteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42212791
DOI: 10.1128/mbio.00939-26
PMCID: PMC13343901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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