Article
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2014
Gonzalo-Asensio Jesús, Malaga Wladimir, Pawlik Alexandre, Astarie-Dequeker Catherine, Passemar Charlotte, Moreau Flavie, Laval Françoise, Daffé Mamadou, Martin Carlos, Brosch Roland, Guilhot Christophe
Abstract excerpt
Although the bovine tuberculosis (TB) agent, Mycobacterium bovis, may infect humans and cause disease, long-term epidemiological data indicate that humans represent a spill-over host in which infection with M. bovis is not self-maintaining. Indeed, human-to-human transmission of M. bovis strains and other members of the animal lineage of the tubercle bacilli is very rare. Here, we report on three mutations...
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