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Functional analysis of the Mycobacterium bovis AF2122/97 PhoPR system.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2024

Urtasun-Elizari Jose Maria, Ma Ruoyao, Pickford Hayleah, Farrell Damien, Gonzalez Gabriel, Perets Viktor, Nakajima Chie, Suzuki Yasuhiko, MacHugh David E, Bhatt Apoorva, Gordon Stephen V

Abstract excerpt

The PhoPR system is a master regulator in Mycobacterium tuberculosis. A key difference between M. tuberculosis and Mycobacterium bovis is a G71I substitution in the M. bovis PhoR orthologue. Functional studies of the M. bovis PhoPR system have generated conflicting findings, with some research suggesting that the M. bovis PhoPR is defective while others indicate it is functional. We sought to revisit the...

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PMID: 39018651
DOI: 10.1016/j.tube.2024.102544

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