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Mycobacterium tuberculosis H37Rv has a single nucleotide polymorphism in PhoR which affects cell wall hydrophobicity and gene expression.

Microbiology (Reading, England) - 1 Apr 2015

Schreuder L J, Carroll P, Muwanguzi-Karugaba J, Kokoczka Rachel, Brown Amanda C, Parish T

Abstract excerpt

Mycobacterium tuberculosis is a successful pathogen that can adapt to multiple environmental niches. As part of its repertoire of adaptive responses, two-component regulatory systems play a major role in co-ordinating gene expression at the global level. The PhoPR system controls major cellular functions, including respiration, lipid metabolism, the immediate and enduring hypoxic responses, stress responses and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25635271
DOI: 10.1099/mic.0.000036

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