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Article

Hepatic CYP1A2 Activity in Adolescents with and without Obesity Assessed by the Urinary Paraxanthine-to-Caffeine Metabolic Ratio: A Pharmacokinetic Study.

Journal of clinical pharmacology - 1 Jun 2026

Gade Christina, Ullah Shahid, Dalhoff Kim, Andersen Jon Trærup, Riis Troels, Holm Jens Christian, Lausten-Thomsen Ulrik

Abstract excerpt

Obesity-related metabolic and hepatic alterations may influence drug metabolism via cytochrome P450 enzymes. While adult studies suggest altered CYP1A2 activity in obesity, data in pediatric populations remain limited and inconclusive. The objective was to assess the in vivo CYP1A2 phenotype in adolescents aged 11-18 years with and without obesity, and to explore sex-based differences in enzyme activity within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42212530
DOI: 10.1002/jcph.70219
PMCID: PMC13366440

Genes

CYP1A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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