Article
CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.
International journal of obesity (2005) - 1 Jan 2022
Gkouskou Kalliopi G, Georgiopoulos Georgios, Vlastos Ioannis, Lazou Evgenia, Chaniotis Dimitrios, Papaioannou Theodore G, Mantzoros Christos S, Sanoudou Despina, Eliopoulos Aristides G
Abstract excerpt
BACKGROUND/OBJECTIVES: Evidence regarding the influence of coffee on appetite and weight control is equivocal and the influence of covariates, such as genetic variation in caffeine metabolism, remains unknown. Herein, we addressed the novel hypothesis that genetic variation in CYP1A2, a gene responsible for more than 95% of caffeine metabolism, differentially impacts the association of coffee consumption with...
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