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Article

Assessment of CYP1A2 activity in clinical practice: why, how, and when?

Basic & clinical pharmacology & toxicology - 1 Sept 2005

Faber Mirko S, Jetter Alexander, Fuhr Uwe

Abstract excerpt

The cytochrome P450 enzyme CYP1A2 mediates the rate-limiting step in the metabolism of many drugs including theophylline, clozapine, and tacrine as well as in the bioactivation of procarcinogens. CYP1A2 activity shows both pronounced intra- and interindividual variability, which is, among other factors, related to smoking causing enzyme induction, to drug intake and to dietary factors which may result in...

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Identifiers

PMID: 16128905
DOI: 10.1111/j.1742-7843.2005.pto_973160.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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