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Article

Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2017

Li Hui, Canet Mark J, Clarke John D, Billheimer Dean, Xanthakos Stavra A, Lavine Joel E, Erickson Robert P, Cherrington Nathan J

Abstract excerpt

Variable drug responses depend on individual variation in the activity of drug-metabolizing enzymes, including cytochrome P450 enzymes (CYP). As the most common chronic liver disease in children and adults, nonalcoholic steatohepatitis (NASH) has been identified as a source of significant interindividual variation in hepatic drug metabolism. Compared with adults, children present age-related differences in...

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Identifiers

PMID: 28986475
DOI: 10.1124/dmd.117.077644
PMCID: PMC5697442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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